(111) Liang, Y.†; Iqbal, Z.†; Lu, J.; Wang, J.; Zhang, H.; Chen, X.; Duan, L.*; Xia, J.*
Cell-Derived Nanovesicle-Mediated Drug Delivery to the Brain: Principles and Strategies for Vesicle Engineering.
Molecular Therapy 2022 Accepted. (Review)

(110) Yuan, D.†; Zhang, Y.†; Lim, K. H.; Leung, S. K. P.; Yang, X.; Liang, Y.; Lau, W. C. Y.; Chow, K. T.*; Xia, J.*
Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes.
J. Am. Chem. Soc. Accepted.

(109) Wang, C.; Li, Y.; Liu, L.; Liu, M.; Chen, X.; Zhou, S.; Cui, P.; Du, X.; Qiu, L.; Wang, J.*; Jiang, P.*; Xia, J.*
Antimicrobial Nanozyme-Enzyme Complex Catalyzing Cascade Reaction of Glucose to Hydroxyl Radical to Combat Bacterial Infection
Journal of Drug Delivery Science and Technology, 2022, accepted.

(108) Liang, Y.; Igbal, Z.; Wang, J.; Xu, L.; Xu, X.; Ouyang, K.; Zhang, H.; Lu, J.; Duan, L.; Xia, J.*
Cell-Derived Extracellular Vesicles for CRISPR/Cas9 Delivery: Engineering Strategies for Cargo Packaging and Loading
Biomaterials Science, 202210, 4095 – 4106.

(107) Shinge, S. A. U.; Xiao, Y.; Xia, J.; Liang, Y.; Duan, L.
New insights of engineering plant exosome-like nanovesicles as a nanoplatform for therapeutics and drug delivery
Extracellular Vesicles and Circulating Nucleic Acids 2022, 3, 150-162.

(106) Wei, Q.; Wang, Y.; Liu, Z.; Liu, M.; Cao, S.; Jiang, H.; Xia, J.*
Multienzyme Assembly on Caveolar Membranes In Cellulo
ACS Catalysis 2022, 12, 8372-8379.

(105) Lei, X.; Li, M.; Wang, C.; Cui, P.; Qiu, L.; Zhou, S.; Jiang, P.; Li, H.; Zhao, D.; Ni, X.; Wang, J.; Xia, J.*
Degradable Microneedle Patches Loaded with Antibacterial Gelatin Nanoparticles to Treat Staphylococcal Infection-Induced Chronic Wounds
International Journal of Biological Macromolecules, 2022, 217, 55-65.

(104) Liang, Y.; Xu, X.; Xu, L.; Ouyang, K.; Zhang, H.; Duan, L.; Xia, J.*
Chondrocyte-Specific Genome Editing Enabled by Hybrid Exosomes for Osteoarthritis Treatment
Theranostics, 2022, 12, 4866-4878.

(103) Wang, Y.†; Liu, M.†; Wei, Q.; Wu, W.; He, Y.; Gao, J.; Zhou, R.; Jiang, L.; Qu, J.; Xia, J.*
Phase-Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote
Angew. Chem. Int. Ed. 2022, e202203909.

(102) Huang, J.; Liu, F.; Su, H.; Xiong, J.; Yang, L.; Xia, J.; Liang, Y.*
Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering
Gels 2022, 8, 138.

(101) Huang, J.; Lei, L.; Huang, Z.; Rong, Z.; Li, H.; Xie, Y.; Duan, L.; Xiong, J.; Wang, D.; Zhu, S.; Liang, Y.*; Wang, J.*; Xia, J.*
Gelatin – Recombinant Type III Collagen Hydrogel to Promote Wound Healing
Int. J. Bioprinting 2022, 8, 517.

(100) Wang, X.; Qiu, L.; Wang, C.; Gao, Z.; Zhou, S.; Cui, P.; Jiang, P.; Hu, H.; Ni, X.*; Du, X.; Wang, J.*; Xia, J.* “Nanodot–doped peptide hydrogel for antibacterial phototherapy and wound healing” Biomater. Sci accepted

CuS nanodots synergize with antibacterial peptide hydrogels to heal infected wounds, an article belonging to Peptides and enzymes against bacterial infection.

(99) Xu, L.; Liang, Y.; Xu, X.; Xia, J.; Wen, C.; Zhang, P.; Duan, L.* “Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems” Bioengineered 2021,

A review article belonging to Engineering exosomes for biomedical research.

(98) Huang, J.; Zhang, J.; Xiong, J.; Sun, S.; Xia, J.*; Yang, L.*; Liang, Y.* “Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing” Stem Cells International 2021,

A review article belonging to Engineering exosomes for biomedical research.

(97) So, W. H#.; Bao, Y.#; Chen, X.; Xia, J.* “On-Resin Ugi Reaction for C-Terminally Modified and Head-to-Tail Cyclized Antibacterial Peptides” Org. Lett. 2021, 23, 8277–8281. (# equal contribution)

A four-component Ugi reaction gives C-terminal photocaged peptide amides, which can be photolyzed to generate C-terminal peptide amides, which paves the road to protein C-terminal modifications and design of enzyme inhibitors, belonging to Protein reactions.

(96) Bao, Y.; Qiu, J.; Xia, J.* “Covalent Reactive Peptides to Block Protein – Protein Interactions and Inhibit Microbe-Host Interaction” Methods in Molecular Biology 2021 in press.

(95) Duan, L.; Ouyang, K.; Wang, J.; Xu, L.; Xu, X.; Wen, C.; Xie, Y.; Liang, Y.*; Xia, J.* “Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing” ChemBioChem 2021,

A review article belonging to Engineering exosomes for biomedical research.

(94) Chen, X.; Liu, M.; Zhang, P.; Xu, M.; Yuan, W.; Bian, L.; Liu, Y. Xia, J.*; Leung, S. S. Y.* “Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter BaumanniiACS Infectious Diseases, revised.

Depolymerase to assist bacterial killing, an article belonging to Peptides and enzymes against bacterial infection.

(93) Wang, R.; Liu, M.; Wang, H.; Xia, J.; Li, H.* “GB Tags: Small Covalent Peptide Tags Based on Protein Fragment Reconstitution” Bioconjugate Chem. 2021, 32, 1926-1934.

A covalent tag, belonging to protein reactions

(92) Ho, M. K. Y.; Zhang, P.; Chen, X.; Xia, J.*; Leung, S. S. Y.* “Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies” Critical Reviews in Microbiology, 2021, 1-24.

A review article belonging to Peptides and enzymes against bacterial infection

(91) Liu, L.; Wang, C.; Li, Y.; Qiu, L.; Zhou, S.; Cui, P.; Jiang, P.; Ni, X.; Liu, R.; Du, X.; Wang, J.*; Xia, J.* “Manganese Dioxide Nanozyme for Reactive Oxygen Therapy of Bacterial Infection and Wound Healing”  Biomater. Sci. 2021, 9, 5965 – 5976.

A review article belonging to Peptides and enzymes against bacterial infection

(90) Feng, L.; Wang, P.; Feng, Y.; Zhang, J.; Chen, Q.; Xie, Y.; Luo, J.; Xia, J.; Yao, S.; Sun, H. “A reversible microarray immobilization strategy based on thiol-quinone reaction” Chin. Chem. Lett. 2021

(89) Zhang, W.; Wu, Y.; Liu, L.; Xiao, X.; Cong, Z.; Shao, N.; Qiao, Z.; Chen, K.; Liu, S.; Zhang, H.; Ji, Z.; Shao, X.; Dai, Y.; He, H.; Xia, J.; Fei, J.; Liu, R. “Membrane-Targeting Mechanism of Host Defense Peptides Inspiring the Design of Polypeptide-Conjugated Gold Nanoparticles Exhibiting Effective Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus” J. Mater. Chem. B 2021, 5092-5101.

(88) Wei, Q.; Xia, J.* “Self-assembled Multienzyme Nanostructures for Biocatalysis in Cellulo” Methods in Molecular Biology 2021, in press. (Book chapter)

(87) Liu, M.; Chen, X.; Xia, J.* “Multienzyme Catalysis in Phase-Separated Protein Condensates” Methods in Molecular Biology 2021, in press. (Book chapter)

(86) Chen, X.; Liu, M.; Zhang, P.; Leung, S. S. Y.*; Xia, J.* “Membrane-Permeable Antibacterial Enzyme against Multidrug-Resistant Acinetobacter baumanniiACS Infect. Dis. 2021, 7, 2192–2204.

An enzyme with outstanding activity against G-ve bacteria, an article belonging to Peptides and enzymes against bacterial infection

(85) Wang, C.; Hong, T.; Cui, P.; Wang, J.*; Xia, J.* “Antimicrobial peptides towards clinical application: delivery and formulation” Adv. Drug Deliv. Rev. 2021, 175, 113818.

A review belonging to Peptides and enzymes against bacterial infection

(84) Li, Q.; Zeng, C.; Liu, H.; Yung, K. W. Y.; Chen, C.; Xie, Q.; Zhang, Y.; Wah, S. W. C.; Mak, B. S. W.; Xia, J.; Xiong, S.; Ngo, J. C. K. “Novel protein–protein interaction inhibitor of SRPKs alters the splicing isoforms of VEGF and inhibits angiogenesis” iScience 2021, 24, 102423.

(83) Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* “Antibacterial photodynamic gold nanoparticles for skin infection” ACS Appl. Bio Mater. 2021, 4, 3124–3132.

Antibacterial photodynamic therapy to treat skin infection, an article belonging to Peptides and enzymes against bacterial infection

(82) Qiu, L.; Wang, C.; Lei, X.; Du, X.; Guo, Q.; Zhou, S.; Cui, P.; Hong, T.; Jiang, P.; Wang, J.*; Li, Y.*; Xia, J.* “Gelatinase-responsive release of antibacterial photodynamic peptide against Staphylococcus aureusBiomater. Sci. 2021, 9, 3433-3444.

Antibacterial photodynamic peptides to treat skin infection, an article belonging to Peptides and enzymes against bacterial infection

(81) Huang, J.; Huang, Z.; Liang, Y.; Yuan, W.; Bian, L.; Duan, L.; Rong, Z.; Xiong, J.*; Wang, D.*; Xia, J.* “3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair” Biomater. Sci. 2021, 9, 2620.

(80) Liang Yujie, Xia, J.* “Non-surgical osteoarthritis therapy, intra-articular drug delivery toward clinical applications” J. Drug Targeting 2021, 1-16.

(79) Liang, Y.; Duan, L.; Lu, J.; Xia, J.* “Engineering exosomes for targeted drug delivery” Theranostics 2021, 11, 3183-3195.

A review article belonging to Engineering exosomes for biomedical research.

(78) Duan, L.; Xu, L.; Xu, X.; Qin, Z.; Zhou, X.; Xiao, Y.; Liang, Y.*; Xia, J.* “Exosome-mediated delivery of gene vectors for gene therapy” Nanoscale 2021, 13, 1387 – 1397. (Featured on back cover).

A review article belonging to Engineering exosomes for biomedical research.

(77) Duan, L*.; Xu, X.; Xu, L.; Chen, H.; Li, X.; Alahdal, M.; Xiao, Y.; Liang, Y.*; Xia, J.* “Exosome-mediated drug delivery for cell-free therapy of osteoarthritis” Curr. Med. Chem. 2021, 28, 6458-6483.  

A review article belonging to Engineering exosomes for biomedical research.

(76) Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* “Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration” Biomaterials 2021, 269, 120539.

Engineering exosomes to deliver a hydrophobic molecule to stem cells to treat osteoarthritis, belonging to Engineering exosomes for biomedical research.


(75) Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* “Antibacterial photodynamic peptides for staphylococcal skin infection” Biomater. Sci. 2020, 8, 6695-6702.

Antibacterial photodynamic peptides to treat skin infection, an article belonging to Peptides and enzymes against bacterial infection

(74) Wei, Q.; He, S.; Qu, J.; Xia, J.* “Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In CelluloBioconjug. Chem. 2020, 31, 2413–2420.

Constructing synthetic organelles (multienzyme complexes templated on virus-like particles) inside E. coli turns on the biosynthesis of terpene, an article belonging to Synthetic organelles for biosynthesis

(73) Xiao, X.; Zhang, S.; Chen, S.; Qian, Y.; Xie, J.; Cong, Z.; Zhang, D.; Zou, J.; Zhang, W.; Ji, Z.; Cui, R.; Qiao, Z.; Jiang, W.; Dai, Y.; Wang, Y.; Shao, X.; Sun, Y.; Xia, J.; Fei, J.; Liu, R. “An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance” Biomater. Sci. 2020, 8, 6883-6889.

(72) Lai, W. C. B.; Chen, X.; Ho, M. K. Y.; Xia, J.; Leung, S. S. Y. “Bacteriophage-derived Endolysins to Target Gram-Negative Bacteria” Int. J. Pharmaceutics 2020, 589, 119833  

(71) Liang, Y.; Duan, L.; Xu, X.; Li, X.; Liu, M.; Chen, H.; Lu, J.*; Xia, J.* “Mesenchymal Stem Cell − Derived Exosomes for Treatment of Autism Spectrum Disorder” ACS Appl. Bio Mater. 2020,3, 6384−6393.

Exosomes from stem cells can enter the brain through the nose and cure autism, an article belonging to Engineering exosomes for biomedical research.

(70) Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* “Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy” ACS Appl. Mater. Interfaces 2020, 12, 36938–36947.

Engineering exosomes to deliver miRNA to chondrocytes to treat osteoarthritis, an article belonging to Engineering exosomes for biomedical research.

(69) Li, L.; Liu, M.; Yue, L.; Wang, R.; Zhang, N.; Liang, Y.; Zhang, L.; Cheng, L.*; Xia, J.*; Wang, R.* “Host–guest protein assembly for affinity purification of methyl-lysine proteomes”Anal. Chem. 2020, 92, 9322–9329.

Site-specific covalent protein reaction enables protein immobilization, belonging to protein reactions

(68) Zhao, P.; Yin, C.; Zhang, Y.; Chen, X.; Yang, B.; Xia, J.; Bian, L. “Mussel Cuticle-Mimetic Ultra-Tough, Self-Healing Elastomers with Double-Locked Nanodomains Exhibit Fast Stimuli-Responsive Shape Transformation” J. Mater. Chem. A 2020, 8, 12463-12471.

(67) Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* “Phase-separated multienzyme biosynthesis” Biomacromolecules 2020, 21, 2391-2399.

Protein aggregates due to phase separation can cluster enzymes and increase cascade biocatalysis in vitro, an article belonging to Synthetic organelles for biosynthesis

(66) Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* “Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism” Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268.

A unique antibacterial mechanism, enabled by a site-specific reaction of Nck SH3.2 inside intestine cells, an article belonging to protein reactions

(65) Lai, S. N.; Zhou, X.; Ouyang, X.; Zhou, H.; Liang, Y.; Xia, J.; Zheng, B. “Artificial Cells Capable of Long-Lived Protein Synthesis by Using Aptamer Grafted Polymer Hydrogel” ACS Synth. Biol. 2020, 9, 76–83.

(64) So, W. H.; Xia, J.* “On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides” Org. Lett. 2020, 22, 214-218.

A new synthetic method to access C-terminal photocaged peptides


(63) Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.* “Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds” ACS Nano 2019, 13, 11343-11352.

Assembling proteins into nanostructures alter their catalytic behavior in vitro, an article belonging to Synthetic organelles for biosynthesis

(62) Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J.*, Liu, T.* “Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux” Nat. Commun. 2019, 10, 4248.

Enzyme assembly constructs a synthetic metabolic node inside E. coli and increases cascade biocatalysis in cells, an article belonging to Synthetic organelles for biosynthesis

(61) Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.* “Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In VivoACS Nano 2019, 13, 9895-9906.

Covalent assembly of three enzymes into nano-machineries increases cascade biocatalysis in E. Coli, an article belonging to Synthetic organelles for biosynthesis

(60) Huang, J.; Liang, Y.; Huang, Z.; Zhao, P.; Liang, Q.; Liu, Y.; Duan, L.; Liu, W.; Zhu, F.; Bian, L.; Xia, J.*, Xiong, J.;* Wang, D.* “Magnetic enhancement of chondrogenic differentiation of mesenchymal stem cells” ACS Biomater. Sci. Eng. 2019, 5, 2200-2207. [Featured on Supplementary Cover]

(59) Zhang, Y.; Liang, Y.; Huang, F.; Zhang, Y.; Li, X.; Xia, J.* “Site-selective lysine reactions guided by protein-peptide interaction” Biochemistry 2019, 58, 1010-1018.

Systemic exploration of proximity-induced lysine reactions, an article belonging to protein reactions

(58) Ma, T.; Shi, B.; Ye, Z.; Li, X.; Liu, M.; Chen, Y.; Xia, J.; Nielsen, J.; Deng, Z.; Liu, T. “Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene” Metab. Eng. 2019, 52:134-142.

(57) Chen, X., Li, R., Wong, S. H. D., Wei, K., Cui, M., Chen, H., Jiang, Y., Yang, B., Zhao, P., Xu, J., Chen, H., Yin, C., Lin, S., Lee, W.Y., Jing, Y., Li, Z., Yang, Z., Xia, J., Chen, G., Li, G., Bian, L. “Conformational manipulation of scale-up prepared single-chain polymeric nanogels for multiscale regulation of cells”  Nat. Commun. 2019, 10, 2705.

(56) Wang, J., Zhu, Z., Jia, W., Qiu, L., Chang, Y., Li, J., Ma, L., You, Y., Wang, J., Liu, L., Xia, J., Liu, X., Li, Y. Q., Jiang, P. “Resolving quantum dots and peptide assembly and disassembly using bending capillary electrophoresis” Electrophoresis 2019, 40, 1019-1026.


(55) Wang, J.; Zhu, Z.; Qiu, L.; Wang, J.; Wang, X.; Xiao, Q.; Xia, J.; Liu, L.; Liu, X.; Feng, W.; Wang, J.; Miao, P.; Gao, L. “A CE-FL based method for real-time detection of in-capillary self-assembly of the nanoconjugates of polycysteine ligand and quantum dot” Nanotechnology 2018, 29, 274001.

(54) Wang, R.; Huang, M.; Li, L.; Kaneko, T.; Voss, C.; Zhang, L.*; Xia, J.*; Li, S. S. C.* “Affinity purification of methyllysine proteome by site-specific covalent conjugation” Anal. Chem. 2018, 90, 13876-13881.

(53) Wang, R.; Leung, P. Y. M.; Huang, F.; Tang, Q.; Kaneko, T.; Huang, M.; Li, Z.; Li, S. S. C.*; Wang, Y.*; Xia, J.* “Reverse binding mode of phosphotyrosine peptides with SH2 protein” Biochemistry 2018, 57, 5257-5269.

(52) Liu, J.; Qu, J.; Zhou, W.; Huang, Y.; Jia, L.; Huang, X.; Qian, Z.; Xia, J.*; Yu. Y.* “Syntenin-targeted peptide blocker inhibits progression of cancer cells” Eur. J. Med. Chem. 2018, 154, 354-366.

(51) Feng, L.; Chhabra, M.; So, W. H.; Zhu, Q.; Xia, J.*; Sun, H.* “A proximity-induced covalent fluorescent probe for selective detection of bromodomain 4” Chin. Chem. Lett. 2018, 29, 1147-1150.

(50) So, W. H.; Wong, C. T. T.; Xia, J.* “Peptide photocaging: a brief account of the chemistry and biological applications” Chin. Chem. Lett. 2018, 29, 1058-1062.

(49) Li, C.; Wu, H.; Zhang, T.; Liang, Y.; Zheng, B.; Xia, J.; Xu, J.; Miao, Q.* “Functionalized p Stacks of hexabenzoperylenes as a platform for chemical and biological sensing.” Chem 2018, 4, 1-11.


(48) Liu, M.; Ji, Z.; Zhang, M.; Xia, J.* “Versatile site-selective protein reaction guided by WW domain–peptide motif interaction,” Bioconjug. Chem. 2017, 28, 2199-2205 (ACS Editor’s choice).

(47) So, W. H.; Zhang, Y.; Kang, W.; Wong, C. T. T.*; Sun, H.*; Xia, J.* “Site-selective covalent reactions on proteinogenic amino acids” Curr. Opin. Biotech. 2017, 48, 220–227 (Invited review).

(46) Yu, Y.; Nie, Y.; Feng, Q.; Qu, J.; Wang, R.; Bian, L.; Xia, J.* “Targeted Covalent Inhibition of Grb2–Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer Cells” Mol. Pharmaceutics 2017, 14, 1548−1557.

(45) Lai, Y.-T.; Yang, Y.; Hu, L.; Cheng, T.; Chang, Y.-Y.; Koohi-Moghadam, M. Wang, Y.; Xia, J.; Wang, J.; Li, H.; Sun. H. “Integration of fluorescence imaging with proteomics enables visualization and identification of metallo-proteomes in living cells” Metallomics 2017, 9, 38-47.


(44) Zhao, B.; Yang, D.; Wong, J. H.; Wang, J.; Yin, C.; Zhu, Y.; Fan, S.; Ng, T. B.*; Xia, J*.; Li, Z.* “Thiol-ether Stabilized DProline-LProline Induced b-Hairpin Peptide of Defensin Segment Increases its Anti-Candida Albicans Ability.” Chembiochem 2016, 17, 1416 – 1420.

(43) Wei, K.; Zhu, M.; Sun, Y.; Xu, J.; Feng, Q.; Lin, S.; Wu, T.; Xu, J.; Tian, F.; Xia, J.; Li, G.; Bian, L. “Robust Biopolymeric Supramolecular “Host−Guest Macromer” Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration” Macromolecules 2016, 49, 866-875

(42) Li, J.; Lee, W. Y.; Wu, T.; Xu, J.; Zhang, K.; Li, G.; Xia, J.; Bian, L. “Multifunctional Quantum Dot Nanoparticles for Effective Differentiation and Long-Term Tracking of Human Mesenchymal Stem Cells In Vitro and In Vivo.” Adv. Healthc. Mater. 2016, 5, 1049-57.

(41) Liu, J.; Liu, M.; Zheng, B.; Yao, Z.; Xia, J.* “Affinity Enhancement by Ligand Clustering Effect Inspired by Peptide Dendrimers-Shank PDZ Proteins Interactions.” PLoS One 2016, 11, e0149580.   

(40) Yu, Y.; Xia, J.* “Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition” Sci. China Chem. 2016, 59, 1-8.

(39) Yu, Y.; Liu, M.; Ng, T. T.; Huang, F.; Nie, Y.; Wang, R.; Yao, Z-P.; Li, Z.; Xia, J.* “PDZ-reactive peptide activates ephrin-B reverse signaling and inhibits neuronal chemotaxis” ACS Chem. Biol. 2016, 11, 149-158.


(38) Huang, F.; Nie, Y.; Ye, F.; Zhang, M.; Xia, J.* “Site selective Azo coupling for peptide cyclization and affinity labeling of an SH3 protein.” Bioconjugate Chem. 2015, 26, 1613-1622.

(37) Ng, T. B.; Cheung, R. C.; Wong, J. H.; Wang, Y.; Ip, D. T.; Wan, D. C.; Xia, J. “Antiviral activities of whey proteins.” Appl. Microbiol. Biotechnol. 2015, 99, 6997-7008.

(36) Yu, Y.; Wang, J.; Liu, J.; Ling, D.; Xia, J.* “Functional assembly of protein fragments induced by spatial confinement” PLoS One. 2015, 10, e0122101.

(35) Kang W.; Liu, J.; Wang, J.; Nie, Y.; Guo, Z.; Xia, J.* “Cascade Biocatalysis by Multienzyme-Nanoparticle Assemblies” Bioconjugate Chem. 2014, 25, 1387-1394.

(34) Lu, Y.; Huang, F.; Wang, J.; Xia, J.* “Affinity-Guided Covalent Conjugation Reaction Based on PDZ-Peptide and SH3-Peptide Interactions” Bioconjugate Chemistry, 2014, 25, 989-999. [Featured on Cover]

(33) Ling, D.; Gao, L.; Wang, J.; Shokouhimehr, M.; Liu, J.; Yu, Y.; Hachett, M. J.; So, P.; Zheng, B.; Yao, Z.; Xia, J.*; Hyeon, T.* “A General Strategy for Site-Directed Enzyme Immobilization by Using NiO Nanoparticle Decorated Mesoporous Silica” Chem. Eur. J. 2014, 20, 7916-7921.

(32) Xie, S.; Lu, Y.; Jakoncic, J.; Sun, H.; Xia, J.; Qian, C. “Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins” FEBS J. 2014, doi: 10.1111/febs.12867.

(31) Cheung, R. C. F.; Wong, J. H.*; Pan, W. L.; Chan, Y. S.; Yin, C. M.; Dan, X. L.; Wang, H. X.; Fang, E. F.; Lam, S. K.; Ngai, P. H. K.; Xia, L. X.; Liu, F.; Ye, X. Y.; Zhang, G. Q.; Liu, Q. H.; Sha, O.; Lin, P.; Ki. C.; Bekhit, A. A.; Bekhit, A. E.; Wan, D. C. C.; Ye, X. J.*; Xia, J.*; Ng, T. B.* “Antifungal and Antiviral Products of Marine Organisms” Appl. Microbiol. Biotechnol. 2014, 98, 3475-3494. Cited 23 times.

(30) Wang, J.; Yu, Y.; Xia, J.* “Short Peptide Tag for Covalent Protein Labeling Based on Coiled Coils” Bioconjugate Chemistry, 2014, 25, 178-187. [Featured on cover]

(29) Wang, J.; Nie, Y.; Lu, Y.; Liu, J.; Wang, J.; Fu, A.; Liu, T.; Xia, J.* “The Assembly of Multivalent Protein Ligands and Quantum Dots: A Multifaceted Investigation” Langmuir, 2014, 30, 2161−2169.   [Featured on cover]

(28) Wang, J.; Jiang, P.; Qiu, L.; Wang, C.; Xia, J.* “Resolving antibody–peptide complexes with different ligand stoichiometries reveals a marked affinity enhancement through multivalency” Talanta, 2013, 115, 394–400.

(27) Wang, J.; Qiu, L.; Wang, C.; Zhang, Y.; Li, J.; Xia, J.*; Jiang, P.* “Probing Antigen-Antibody Interaction Using Fluorescence Coupled Capillary Electrophoresis” International Journal of Molecular Sciences,2013, 14, 19146-19154.

(26) Wang, J.; Jiang, P.; Gao, L.; Yu, Y.; Lu, Y.; Qiu, L.; Wang, C.; Xia, J.* “Unique self-assembly properties of a bridge-shaped protein dimer with quantum dots” Journal of Nanoparticle Research, 2013, 15, 1914-1919.

(25) Yin, C.; Wong, J. H., Xia, J.; Ng, T. “Studies on anticancer activities of Lactoferrin and Lactoferricin” Current Protein and Peptide Science 2013, 6, 492-503.

(24) Wang, J.; Li, Z.; Qiu, L.; Wang, C.; Jiang, P.; Cho, C.; Xia, J.* “Homing Peptide Conjugated Quantum Dots for Colorectal Cancer Imaging (in Chinese)” Chinese Science Bulletin, 2013, 58, 556–560. 

(23) Lu, Y.; Wang, J.; Wang, J.; Wang, L.; Au, S. W-N.; Xia, J.* “Genetically Encodable Design of Ligand “Bundling” on the Surface of Nanoparticles” Langmuir, 2012, 28, 13788-13792.

(22) Wang, J.; Jiang, P.; Han, Z.; Qiu, L.; Wang, C.; Zheng, Bo.; Xia, J.* “Fast Self-assembly Kinetics of Quantum Dots and a Dendrimeric Peptide Ligand” Langmuir, 2012, 28, 7962–7966.

(21) Wang, J.; Jin, X.; Liu, J.; Khosla, C.*; Xia, J.* “Resolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease” Chemistry – An Asian Journal, 2012, 7, 992-999. (, equal contribution)

(20) Brown, J. M.; Xia, J.; Zhuang, B.; Cho, K-S.; Rogers, C. J.; Gama, C. I.; Rawat, M.; Tully, S.E.; Uetani, N.; Mason, D.; Tremblay, M. L.; Peter, E.C.; Habuchi, O.; Chen, D.F.; Hsieh-Wilson, L.C. “A Sulfated Carbohydrate Epitope Inhibits Axon Regeneration After Injury”, Proceedings of the National Academy of Sciences 2012, 109, 4768-4773. (†, equal contribution)

(19) Wang, J.; Xia, J.* “Capillary Electrophoretic Studies on Displacement and Proteolytic Cleavage of Surface Bound Oligohistidine Peptide on Quantum Dots” Analytica Chimica Acta 2012, 709, 120-127.

(18) Wang, J.; Xia, J.* “Preferential Binding of a Novel Polyhistidine Peptide Dendrimer Ligand on Quantum Dots Probed by Capillary Electrophoresis” Analytical Chemistry 2011, 83, 6323-9.

(17) Wang, J.; Yue, Y.; Chen, G.; Xia, J.* “Protease-Promoted Drug Delivery Using Peptide-Functionalized Gold Nanoparticles” Soft Matter 2011, 7, 7217-7222.

(16) Luo, S.*; Ling, C.; Hu, X.; Liu, X.; Chen, S.; Han, M.; Xia, J. “Thermoresponsive unimolecular micelles with a hydrophobic dendritic core and a double hydrophilic block copolymer shell” Journal of Colloid and Interface Science, 2011, 353, 76-82.


(15) Siegel, M.; Xia, J.; Khosla, C. “Structure-based design of α-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2” Bioorganic and Medicinal Chemistry, 2007, 15(18), 6253-61 (equal contribution).

(14) Xia, J.; Bergseng, E.; Siegel, M.; Fleckenstein, B.; Kim, C. Y.; Sollid, L.M.; Khosla, C. “Cyclic and Dimeric Gluten Peptide Analogues to Inhibit DQ2-Mediated Antigen Presentation in Celiac Disease” Bioorganic and Medicinal Chemistry, 2007, 15, 6565-73.

(13) Xia, J.; Siegel, M.; Bergseng, E.; Sollid, L. M.; Khosla, C. “Inhibition of HLA-DQ2 mediated antigen presentation by analogues of a high affinity 33-residue peptide from a2-Gliadin” Journal of the American Chemical Society, 2006, 128, 1859-67.

(12) Siegel, M.; Bethune, M.T.; Gass, J.; Ehren, J.; Xia, J.; Johannsen, A.; Stuge, T.; Gray, G. M.; Lee, P. P.; Khosla, C. “Rational design of combination enzyme therapy for Celiac Sprue” Chemistry & Biology, 2006, 13, 649-58.

(11) Bergseng, E.; Xia, J.; Kim, C. Y.; Khosla, C.; Sollid, L. M. “Main chain hydrogen bond interactions in the binding of proline rich gluten peptides to the celiac disease associated HLA-DQ2 molecule” Journal of Biological Chemistry, 2005, 280, 21791-6.

(10) Xia, J.; Sollid, L. M.; Khosla, C. “Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2” Biochemistry, 2005, 44, 4442-9.

(9) Qiao, S. W.; Bergseng, E.; Molberg, O.; Xia, J.; Fleckenstein, B.; Khosla, C.; Sollid, L. M. “Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion” Journal of Immunology, 2004, 173, 1757-1762.

Before 2004

(8)  Xia, J.; Shi, Y. B.; Zhang, Y.; Miao, Q.; Tang, W. X. “Deprotonation of zinc(II)-water and zinc(II)-alcohol and nucleophilicity of the resultant zinc(II) hydroxide and zinc(II) alkoxide in double-functionalized complexes: Theoretical studies on models for hydrolytic zinc enzymes” Inorganic Chemistry, 2003, 42, 70-77.

(7) Li, S. A.; Xia, J.; Yang, D. X.; Xu, Y.; Li, D. F.; Wu, M. F.; Tang, W. X. “Carboxyester hydrolysis catalyzed by a novel dicopper(II) complex with an alcohol-pendant macrocycle” Inorganic Chemistry, 2002, 41, 1807-1815.

(6) Yang, D. X.; Li, S. A.; Li, D. F.; Xia, J.; Yu, K. B.; Tang, W. X. “Synthesis and properties of a dizinc complex of a novel macrocyclic ligand with two alcohol-pendants: A model for alkaline phosphatase” Journal of the Chemical Society-Dalton Transactions, 2002, 21, 4042-4047.

(5)  Xia, J.; Li, S. A.; Shi, Y. B.; Yu, K. B.; Tang, W. X. “Elucidation of the mechanism of carboxy ester cleavage promoted by a Cu(II) alkoxide complex of a tripodal ligand (N3OX)” Journal of the Chemical Society-Dalton Transactions, 2001, 14, 2109-2115.

(4)  Xia, J.; Sun, W. Y.; Xu, Y.; Yu, K. B.; Tang, W. X. “Hydrogen bonds in the framework of bis{2-[bis(2-aminoethyl)amino]ethanol}nickel(II) diperchlorate” Acta Crystallographica Section C, 2001, 57, 38-39.

(3)  Xia, J.; Xu, Y.; Li, S. A.; Sun, W. Y.; Yu, K. B.; Tang, W. X. “Carboxy ester hydrolysis promoted by a Zinc(II) 2-[bis(2-aminoethyl)amino]ethanol complex: A new model for indirect activation on the serine nucleophile by Zinc(II) in Zinc enzymes” Inorganic Chemistry, 2001, 40, 2394-2401.

(2)  Li, S. A.; Li, D. F.; Duan, C. Y.; Xia, J.; Yang, D. X.; Tang, W. X. “A new dicopper(II) complex with macrocyclic hexaaza bearing hydroxyethyl pendants” Inorganic Chemistry Communications, 2001, 4, 651-655.

(1)  Li, S. A.; Liu, Y. J.; Xia, J.; Li, D. F.; Tang, W. X. “Crystal structure of a 26-membered hexaaza macrocycle bearing hydroxyethyl pendants containing p-xylyl spacers” Journal of Chemical Crystallography, 2000, 30, 743-747.